Research Environment

Complex Systems Chemistry is a new approach to chemistry in the 21st century, that will lead to profound advanced technological changes.

The art of pastry: a graphene mille-feuille for highly sensitive health monitoring More informations

Oscillating artificial microtubules:     the work opens new pathways to obtain life-like artificial systems and materials, which can perform complex biological functions such as cell division in the future. More informations

Innovation Investment example of CSC – Project CHIRALRES

How to separate under mild conditions chiral compounds without column

This project is managed by Thomas Hermans, director of the Laboratoire des Systèmes complexes hors équilibre at the Institut de Science et d’Ingénierie Supramoléculaire (ISIS – Unistra CNRS). ChiralRes is about an adapting process aiming to separate nanometer-sized particles, i.e. both on proteins and anti-bodies. This process already offers the possibility to separate enantiomers without using several chiral stationary phases, which are very costly for pharmaceutical industries. This mild technic would also function to separate mixes of proteins and/or antibodies without risk of degradation.

The investment granted by Conectus Alsace allows the research team to:

• Determine the potential of this separation technique
  — Which minimal particle size would be possible to separate
  — What types of material would fit the best to this technique
• Develop a prototype compatible with the wished separation

More than 200 publications in international reviews in 2017, such as :

• Al Ouahabi, A.; Amalian, J. A.; Charles, L.; Lutz, J. F., Mass spectrometry sequencing of long digital polymers facilitated by programmed inter-byte fragmentation. Nature Communications 2017, 8
• Armao, J. J.; Nyrkova, I.; Fuks, G.; Osypenko, A.; Maaloum, M.; Moulin, E.; Arenal, R.; Gavat, O.; Semenov, A.; Giuseppone, N., Anisotropic Self-Assembly of Supramolecular Polymers and Plasmonic Nanoparticles at the Liquid Liquid Interface. Journal of the American Chemical Society 2017, 139 (6), 2345-2350.
• Carrara, S.; Arcudi, F.; Prato, M.; De Cola, L., Amine-Rich Nitrogen-Doped Carbon Nanodots as a Platform for Self-Enhancing Electrochemiluminescence. Angewandte Chemie-International Edition 2017, 56 (17), 4757-4761.
• Engel, E. R.; Jouaiti, A.; Bezuidenhout, C. X.; Hosseini, M. W.; Barbour, L. J., Activation-Dependent Breathing in a Flexible Metal-Organic Framework and the Effects of Repeated Sorption/Desorption Cycling. Angewandte Chemie-International Edition 2017, 56 (30), 8874-8878.
• Fores, J. R.; Mendez, M. L. M.; Mao, X. Y.; Wagner, D.; Schmutz, M.; Rabineau, M.; Lavalle, P.; Schaaf, P.; Boulmedais, F.; Jierry, L., Localized Supramolecular Peptide Self-Assembly Directed by Enzyme-Induced Proton Gradients. Angewandte Chemie-International Edition 2017, 56 (50), 15984-15988
• Harkat, M.; Peverini, L.; Cerdan, A. H.; Dunning, K.; Beudez, J.; Martz, A.; Calimet, N.; Specht, A.; Cecchini, M.; Chataigneau, T.; Grutter, T., On the permeation of large organic cations through the pore of ATP-gated P2X receptors. Proceedings of the National Academy of Sciences of the United States of America 2017, 114 (19), E3786-E3795.
• Muchowska, K. B.; Varma, S. J.; Chevallot-Beroux, E.; Lethuillier-Karl, L.; Li, G.; Moran, J., Metals promote sequences of the reverse Krebs cycle. Nature Ecology & Evolution 2017, 1 (11), 1716-1721.
• Orecchioni, M.; Bedognetti, D.; Newman, L.; Fuoco, C.; Spada, F.; Hendrickx, W.; Marincola, F. M.; Sgarrella, F.; Rodrigues, A. F.; Menard-Moyon, C.; Cesareni, G.; Kostarelos, K.; Bianco, A.; Delogu, L. G., Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells. Nature Communications 2017, 8.
• Schmidtgall, B.; Chaloin, O.; Bauer, V.; Sumyk, M.; Birck, C.; Torbeev, V., Dissecting mechanism of coupled folding and binding of an intrinsically disordered protein by chemical synthesis of conformationally constrained analogues. Chemical Communications 2017, 53(53), 7369-7372.
• Zhong, X. L.; Chervy, T.; Zhang, L.; Thomas, A.; George, J.; Genet, C.; Hutchison, J. A.; Ebbesen, T. W., Energy Transfer between Spatially Separated Entangled Molecules. Angewandte Chemie-International Edition 2017, 56 (31), 9034-9038